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Diclofenac sodium topical gel price and composition (in U.S. dollars) Table 1 Comparison of N-Acetylpyrrolidone (Tazorac), Diphenylamine Hydroxamic Acid (Diphenoxylate), N,N'-Dimethylaniline (Sevinox), Diphenylamine, Diclofenac 100mg $97.36 - $0.36 Per pill Cinnarizine, Diphenoxypropyl-2-propyl-aminopropane sulfonate (CDPAP-S), Diclofenac, N,N'-Dimethylaniline, Sevinox (Tazorac), Diclofenac sodium, sodium topical gel and Cinnarizine (Sevinox, Tazorac), Tazorac, Diphenylamine, N,N'-Dimethylaniline, Diphenylamine N-Acetylpyrrolidone (Tazorac) Tazorac has the highest concentrations of each ingredient in its formulation and is the most expensive drug in this class. The N-acetylpyrrolidone (Tazorac) is an oral gel formulation composed of a methylated (methylphenidate) salt with the following ingredients: Tazorac (3,4), methylphenidate (2,5 mg), sodium polyacrylate (0.4 g) and dimethylpolysiloxane (4 mg). The formulations were developed by Longex Corporation. The drug is available in 10 mg, 15 30 and 40 mg strengths. Each dosage unit contains the product and a matching placebo. The product is a gel designed for maximum absorption, and is effective for at least 6 months in treating ADHD children and adolescents. The manufacturer states that efficacy of Tazorac is demonstrated by its ability to improve behavior in healthy adults and with ADHD. There have been no known adverse events associated with tazaac use. This review focuses on the average cost of this particular drug, and the composition of formulations with respect to efficacy, toxicity, and adverse events. Tazorac Tazorac is a prescription drug manufactured by Longex Corporation. The drug contains 2.5 mg of methylphenidate (Ritalin, Concerta, Adderall XR) in an ointment base. The drug includes a 20 µg povidone iodine gel with sodium polyacrylate and an aluminum hydroxide sheet in lieu of a preservative as in the other amphetamines (i.e., amphetamine salts). The product is available for treatment of ADHD in adolescents and adults. The label indicates that this product treats ADHD symptoms in adults, but a study has shown that the average daily dose in both the treatment of ADHD in school children and those with other attention-deficit/hyperactivity disorder symptoms is less than 20 mg/day and that the average daily dose is below 10 mg/day in treatment of ADHD school children.2 The product was tested in two controlled clinical studies of the medication (A. J. Longex, Ph.D., a former employee of Janssen-Cilag Pharma Ltd., a division of Johnson & Johnson) as an alternative treatment for adults with ADHD. In one study of adults at two treatment sites, the average daily dose of 40 mg product was 9.6 mg/day with a standard deviation of 1.8 mg or 15.6 mg/day.3 In the second study, conducted two pediatric diclofenac sodium topical gel price treatment sites, the average daily dose was 19.1 mg/day with a standard deviation of 6.1 mg or 20.2 mg/day.4 In both studies the mean baseline diclofenac potassium online and change from were within the range for those who are receiving ADHD treatment. In both studies, subjects receiving all three dose combinations experienced significant improvement compared to the placebo group.



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